We describe a cryogenic instrumentation platform incorporating commercially-available field-programmable gate arrays (FPGAs) configured to operate well beyond their specified temperature range. The instrument enables signal routing, multiplexing, and complex digital signal processing at temperatures approaching 4 kelvin and in close proximity to cooled devices or detectors within the cryostat. The cryogenic performance of the system is evaluated, including clock speed, error rates, and power consumption. Although constructed for the purpose of controlling and reading out quantum computing devices with low latency, the instrument is generic enough to be of broad use in a range of cryogenic applications.
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